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- Title
Improvement of patient stratification in human papilloma virus‐associated oropharyngeal squamous cell carcinoma by defining a multivariable risk score.
- Authors
Oberste, Maximilian; Riders, Armands; Abbaspour, Bektasch; Kerschke, Laura; Beule, Achim G.; Rudack, Claudia
- Abstract
Background: Precise risk stratification models are necessary to determine patient selection for deintensifying treatment trials in human papilloma virus (HPV)‐associated oropharyngeal squamous cell cancer (HPV+ OPSCC). Methods: We examined 526 cases with OPSCC treated at our department between 2002 and 2017. Every patient was classified after the 7th and 8th edition UICC staging manual. For HPV+ OPSCC, we calculated a simple risk score with four risk groups based on multivariable Cox regression analysis of clinical and lifestyle parameters (UICC 8th edition stage, tobacco/alcohol abuse, age, gender). Results: Two hundred and thirty‐nine patients with OPSCC (45.4%) showed a positive histological HPV status. In comparison to UICC 8th edition stages, our proposed risk model showed a tendency for better stratification between risk strata I/III, I/IV, and II/IV (each p < 0.002) and I/II, II/III, and III/IV (each p < 0.09). Conclusion: Age, gender, tobacco, and alcohol abuse should be added to the current UICC staging system in order to improve risk stratification in HPV+ OPSCC.
- Subjects
SQUAMOUS cell carcinoma; PAPILLOMAVIRUSES; PAPILLOMA; PATIENT selection; ALCOHOLISM
- Publication
Head & Neck, 2021, Vol 43, Issue 11, p3314
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26822