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- Title
Genetic Regulation of Bone Traits Is Influenced by Sex and Reciprocal Cross in F2 Progeny From GK and F344 Rats.
- Authors
Lagerholm, Sofia; Luo-Sheng Li; Hong Jiao; Hee-Bok Park; Ohlsson, Claes; Akesson, Kristina; Luthman, Holger
- Abstract
The article reports on the results of research conducted to determine whether the genetic regulation of bone traits is influenced by sex and reciprocal cross in F2 progeny rats and to locate genome regions with genes affecting trabecular and cortical bone. Researchers found that the activation of the transcription factor osterix in growing bones delayed osteoblast maturation, reduced osteoblast function for bone formation and plays a role in regulating bone formation in rats.
- Subjects
BONE growth; SKELETAL maturity; LABORATORY rats; TRANSCRIPTION factors
- Publication
Journal of Bone & Mineral Research, 2009, Vol 24, Issue 6, p1066
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/jbmr.081252