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- Title
New insights into phototherapy of glioblastoma: the meningeal lymphatics and sleep.
- Authors
Shirokov, Alexander; Ilukov, Egor; Blokhina, Inna; Terskov, Andrey; Adushkina, Viktoria; Zlatogosrkaya, Daria; Telnova, Valeria
- Abstract
The meningeal lymphatics (MLVs) play an important role in immunity and maintaining homeostasis of the central nervous system. Sleep is a natural state when lymphatic drainage becomes maximally active and, along with the flow of fluids, toxins and metabolites are removed from the brain. A decrease in function of MLVs is a key mechanism in the development of glioblastoma (GBM), which leads to the accumulation of excess fluid in the brain and an increase in intracranial pressure. Recently, promising methods of transcranial photostimulation (tPBM) of MLVs have been developed. It is interesting to note that tPBM of MLVs during sleep vs. wakefulness stimulates lymphatic drainage of brain tissues much more effectively. It is logical to expect that tPBM of MLVs during sleep will significantly increase the effectiveness of the GBM therapy. This review highlights new trends in the treatment of GBM, including tPBM of MLVs during sleep as a promising strategy in suppression of tumor progression.
- Subjects
GLIOBLASTOMA multiforme; INTRACRANIAL pressure; LYMPHATICS; SLEEP; FLUID flow; DURA mater; WAKEFULNESS; MENINGES; HOMEOSTASIS
- Publication
European Physical Journal: Special Topics, 2024, Vol 233, Issue 3, p691
- ISSN
1951-6355
- Publication type
Article
- DOI
10.1140/epjs/s11734-023-01083-1