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- Title
Mechanisms of Obesity Induced Higher Intestinal Permeability.
- Authors
Khan, Jesmine; Islam, Mohammed Nasimul
- Abstract
Background: Consumption of High fat diet and obesity has been reported to increase small intestinal permeability. In addition to the usual function of digestion and absorption of nutrients, gastrointestinal mucosa functions as a barrier to prevent the entrance of harmful agents into the systemic circulation and protects living organisms from different noxious agents. Any disruption of the gut barrier function might play a role in high fat diet and obesity induced intestinal and extra intestinal pathology. Underlying mechanisms of this process is poorly understood. Objectives: To review the mechanisms underlying high fat diet and or obesity induced higher intestinal permeability. Methods: We searched the related articles in PubMed, Scopus and Google Scholar from January 1980 till August 2011. Results: We found 58 studies using the key words high fat diet, obesity, gut barrier, intestinal permeability, claudin, occludin, junctional adhesion molecule and intestinal tight junction proteins. Only 6 of them evaluated intestinal permeability. Consumption of high fat diet and or obesity was found to be associated with compromised intestinal tight junction proteins. Conclusion: Understanding the mechanisms and modulation of tight junction proteins by nutrients or pharmaceutical agents will prevent different intestinal and extra intestinal pathologies.
- Subjects
DIET; FAT content of food; SMALL intestine; OBESITY; PERMEABILITY
- Publication
International Medical Journal, 2012, Vol 19, Issue 4, p307
- ISSN
1341-2051
- Publication type
Article