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- Title
Dopaminergic Striatal Innervation Predicts Interlimb Transfer of a Visuomotor Skill.
- Authors
Isaias, Ioannis U.; Moisello, Clara; Marotta, Giorgio; Schiavella, Mauro; Canesi, Margherita; Perfetti, Bernardo; Cavallari, Paolo; Pezzoli, Gianni; Ghilardi, M. Felice
- Abstract
Weinvestigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.
- Subjects
DOPAMINE; DENERVATION; PARKINSON'S disease patients; ARM; MOTOR learning; PHYSIOLOGICAL adaptation; CAUDATE nucleus
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 41, p14458
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3583-11.2011