We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Spinal 5-HT3 Receptor Activation Induces Behavioral Hypersensitivity via a Neuronal-Glial-Neuronal Signaling Cascade.
- Authors
Ming Gu; Miyoshi, Kan; Dubner, Ronald; Wei Guo; Shiping Zou; Ke Ren; Noguchi, Koichi; Feng Wei
- Abstract
The article presents a study on the effect of activation of serotonin (5-HT) receptors within the spinal dorsal horn on development of chronic pain after tissue and nerve injury. It reveals that activation of 5-HT receptors induces hyperalgesia through interactions between neurons and glial cells in the spinal cord involving chemokine signaling molecules. It is suggested that pain therapies should focus on blocking of intercellular signaling transduction between neurons and glial cells.
- Subjects
SEROTONIN; CELL receptors; CHRONIC pain; TISSUE wounds; NERVOUS system injuries; HYPERALGESIA; NEUROGLIA; CELLULAR signal transduction
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 36, p12823
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1564-11.2011