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- Title
Molecular characterization of allergens and component‐resolved diagnosis of IgE‐mediated mango fruit allergy.
- Authors
Zhao, Lan; Xie, Hanbing; Wang, Xuefeng; Liu, Meiling; Ma, Tingting; Fu, Wanyi; Wang, Yuqi; Wu, Dongya; Feng, Yan; Liu, Yi; Wu, Shandong; Zhang, Xianqi; Wang, Huiying; Luo, Fangmei; Guo, Baohua; Wu, Hongxia; Yu, Yongmei; Fu, Linglin; Valenta, Rudolf; Vrtala, Susanne
- Abstract
Of the 73 patients, 53 (72.6%) were positive for at least one of the four allergen components; only 30 (41.1%) were positive for mango extract in ImmunoCAP, suggesting low or lacking presence of relevant allergens in the mango extract. Mango allergy is frequently associated with pollinosis by I Artemisia i and I Betula i pollens.[[1]] Immunoglobulin E (IgE)-mediated mango allergy is the leading cause of fruit allergies in China.[3] Although several mango allergens have been identified with IgE-binding bands around 14, 17, 30, 40, 50, 60, and 67 kDa,[[2], [4], [6]] their molecular characterization is absent from the International Union of Immunological Societies (IUIS) allergen database. Specific IgE positivity against mango extract and allergen components was higher in children and teenagers than in adults (Figure 1G), indicating the increasing trend of mango allergy in younger people.
- Subjects
MILK allergy; MANGO; ALLERGENS; FRUIT; ALLERGIES; LIPID transfer protein
- Publication
Allergy, 2023, Vol 78, Issue 6, p1699
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15664