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- Title
GATA‐3 and T‐bet as diagnostic markers of non‐esophageal eosinophilic gastrointestinal disease.
- Authors
Neely, Joseph L.; Reimers, Annika; Taylor, Steve; Garg, Shipra; Masuda, Mia Y.; Schroeder, Shauna; Wright, Benjamin L.; Doyle, Alfred D.
- Abstract
Keywords: eosinophilic enteritis; eosinophilic gastritis; eosinophilic gastrointestinal disease; GATA-3; pediatric subjects; T-bet EN eosinophilic enteritis eosinophilic gastritis eosinophilic gastrointestinal disease GATA-3 pediatric subjects T-bet 1042 1044 3 03/02/22 20220301 NES 220301 ACKNOWLEDGEMENTS The study was funded by Mayo Clinic, Phoenix Children's Hospital Foundation, and the Donald R. Levin Family Foundation. We recently examined T-bet and GATA-3 expression in biopsies from pediatric subjects with EoE, proton pump inhibitor-responsive EoE, and controls and found that both T-bet and GATA-3 expression were increased in EoE subjects.3 This study expands on our initial findings by examining these nuclear transcription factors in subjects with eosinophilic gastritis and/or duodenitis. Slides were digitized and analyzed as previously described.3 Percentages of T-bet+and GATA-3+ nuclei were correlated to tissue eosinophil counts and compared between EG/EoD cases and controls.
- Subjects
GASTROINTESTINAL diseases; EOSINOPHILIC esophagitis; REGULATORY T cells; GASTROINTESTINAL mucosa; T helper cells
- Publication
Allergy, 2022, Vol 77, Issue 3, p1042
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15171