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- Title
Local inflammation enables a basophil‐neuronal circuITCH in atopic dermatitis.
- Authors
López‐Sanz, Celia; Jimenéz‐Saiz, Rodrigo; Ehlers, Anna M.
- Abstract
Additionally, they performed basophil depletion experiments using an antibody against the murine basophil activation marker CD200R in wild-type mice, and diphtheria toxin (DT) in Bas-TRECK mice, which exclusively express the DT receptor on basophils. Keywords: allergic inflammation; atopic dermatitis; basophils; leukotriene C; neuroimmunology EN allergic inflammation atopic dermatitis basophils leukotriene C neuroimmunology 708 710 3 02/01/22 20220201 NES 220201 Abbreviations AD atopic dermatitis CCL C-C chemokine ligand CCR C-C chemokine receptor CysLTR Cysteinyl leukotriene receptor DT diphtheria toxin HR histamine receptor LT leukotriene MCs mast cells OVA ovalbumin Allergic inflammation is often the result of a dysregulated Th2 immune response, IgE production, and the release of allergic mediators such as histamine or leukotrienes (LTs) by basophils and mast cells (MCs). Local inflammation enables a basophil-neuronal circuITCH in atopic dermatitis.
- Subjects
ATOPIC dermatitis; ITCHING; URTICARIA; CELL adhesion molecules; THYMIC stromal lymphopoietin; DORSAL root ganglia; INFLAMMATION
- Publication
Allergy, 2022, Vol 77, Issue 2, p708
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15026