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- Title
COMPARISON OF GLYCOSYLATED HEMOGLOBIN AND FASTING PLASMA GLUCOSE WITH TWO-HOUR POST-LOAD PLASMA GLUCOSE IN THE DETECTION OF DIABETES MELLITUS.
- Authors
SIMON, D.; COIGNET, M. C.; THIBULT, N.; SENAN, C.; ESCHWEGE, E.
- Abstract
In the course of a screening for diabetes mellitus in the Hôtel-Oieu Hospital in Paris, from September 15, 1981 to April 1, 1984, an oral glucose tolerance test and a measurement of glycosytated hemoglobin were performed on 333 outpatients. With two-hour plasma glucose as a reference, the sensitivities of glycosylated hemoglobin, fasting plasma glucose, and a combination of glycosyiated hemoglobin and fasting plasma glucose equal, respectively, 60.0%, 52.0%, and 40.0%; the specificities 90.9%, 98.7%, and 99.4%; the predictive value for a positive diagnosis 34.9%, 76.5%, and 83.3%. If one takes into account the implications of diabetes mellitus, especially its economic and psycnosodologtc consequences, it seems better for diagnosis—from a public health point of view—to use tests with a high degree of specificity and a high predictive value for a positive diagnosis, such as the combination of fasting plasma glucose and glycosyiated hemoglobin, than tests with a good sensitivity but poor specificity. In the long term, validation of glycosyiated hemoglobin as a diagnostic test for asymptomatic diabetes mellitus will be obtained only by reference to unquestionable criteria of the disease, determined by longitudinal survey.
- Publication
American Journal of Epidemiology, 1985, Vol 122, Issue 4, p589
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/oxfordjournals.aje.a114138