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- Title
Skeletal muscle GLUT4 protein concentration and aging in humans.
- Authors
Houmard, Joseph A.; Weidner, Melinda D.; Dolan, Patricia L.; Leggett-Frazier, Nancy; Gavigan, Karen E.; Hickey, Matthew S.; Tyndall, Gilian L.; Donghai Zheng; Alshami, Ayman; Dohm, G. Lynis; Houmard, J A; Weidner, M D; Dolan, P L; Leggett-Frazier, N; Gavigan, K E; Hickey, M S; Tyndall, G L; Zheng, D; Alshami, A; Dohm, G L
- Abstract
The insulin resistance of aging has been attributed to a postreceptor defect in skeletal muscle. The present study examined whether a reduction in the concentration of the insulin-stimulated glucose transporter (GLUT4) in skeletal muscle was associated with advancing age in men (n = 55) and women (n = 29). Insulin sensitivity (minimal model) was negatively associated (P < 0.001) with age (range, 18-80 years) in men (r = -0.44) and women (r = -0.58). GLUT4 protein concentration in the vastus lateralis was also negatively associated (P < 0.05) with age (men, r = -0.28; women, r = -0.51). There was no relation (P > 0.15) between GLUT4 content in the gastrocnemius and age. GLUT4 concentration in the vastus lateralis was positively associated (P < 0.01) with insulin sensitivity in both sexes (r = 0.42); this relationship persisted in the men after adjusting for overall adiposity, regional adiposity, and cardiorespiratory fitness. These findings suggest that a decrement in GLUT4 protein concentration in skeletal muscle may at least partially contribute to the insulin resistance of aging in humans.
- Publication
Diabetes, 1995, Vol 44, Issue 5, p555
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.44.5.555