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- Title
Concomitant Non-V600E BRAF and KRAS Mutations in Colorectal Carcinoma by Next-Generation Sequencing: A Distinct Subtype.
- Authors
Srivastava, Pallavi; Mishra, Sridhar; Shukla, Saumya; Sharma, Pooja; Husain, Nuzhat
- Abstract
The RAS-RAF-MEK-ERK signaling cascade is the most frequently affected signaling pathway in colorectal cancer. BRAFV600E mutations serve as a drug-treatable hotspot and KRAS mutations as a predictor of susceptibility to anti-epidermal growth factor receptor therapy. Concomitant non-V600E BRAF and KRAS mutations may coexist and are rarely reported in the literature. We report a patient of colorectal carcinoma with inguinal lymph node metastases harboring mutations at the KRAS and BRAF non-V600E mutation codon detected by next-generation sequencing with an emphasis on clinical, pathological, and therapeutic implications of the mutation and review of the literature.
- Subjects
LITERATURE reviews; COLORECTAL cancer; LYMPHATIC metastasis; NUCLEOTIDE sequencing; BRAF genes
- Publication
International Journal of Surgical Pathology, 2024, Vol 32, Issue 6, p1186
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969231215425