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- Title
Triple-Negative Breast Cancer In Young Women -Indian Scenario.
- Authors
Priya, Veda Padma
- Abstract
OBJECTIVE: To investigate the clinicopathological characteristics and prognosis in young patients with estrogen receptor (ER)- negative, progesterone receptor (PR)-negative, and Her-2-negative (triple-negative) breast cancer (TNBC) in young patients. METHODS: Young patients (< or = 40 years old) with TNBC treated at the Rajiv Gandhi Cancer Institute & research Centre between October 2010 to September 2016 were included in the study. The clinicopathological features and prognosis of those 85 patients were retrospectively analysed. SPSS 23 was used for statistical analyses and Kaplan Meir graph plotted. RESULTS Among 320 young (<=40) patients with breast cancer, 85 patients (26.56%) were triple-negative. The median age was 34.01 years. 85 patients (100%) were diagnosed with invasive ductal carcinoma. 62.35% of the patients were classified as T1 or T2. The TNM stages included: 9 patients in stage I (10.6%), 44 in stage II (51.7%), 32 in stage III (37.64%). The overall disease-free survival (DFS) was 88.2% and stage wise in Stage I-100%, Stage II 97.7% and Stage III was 71.9%. The corresponding overall survival (OS) rate was 98.8% and stagewise in Stage I and II 100%, Stage III 96.9% respectively. 10 patients developed recurrence or metastatic disease during the follow-up period. 9 developed recurrence or metastatic disease within 1 year of surgery while 1 patient developed recurrence 16 months following surgery. CONCLUSION BRCA positive cases in triple negative young.
- Subjects
TRIPLE-negative breast cancer; BREAST cancer; PROGESTERONE receptors; ESTROGEN receptors; DUCTAL carcinoma; PROGRESSION-free survival
- Publication
Journal of Cancer Research & Therapeutics, 2017, Vol 13, pS34
- ISSN
0973-1482
- Publication type
Article