We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns.
- Authors
Khabaz, Mohamad Nidal; Abdelrahman, Amer Shafei; Al-Maghrabi, Jaudah Ahmad
- Abstract
Objective: Several cancers have showed differences in the role of p- AMPK in cancer growth, progression and prognosis, and little is identified regarding the significance of p-AMPK expression in colorectal adenocarcinoma. Therefore, this report will define p-AMPK phenotype in a panel of colorectal carcinomas and explore the relationship between this phenotype and tumor clinicopathological features. Methods: A total of 228 cases comprising 155 large intestine cancers and 73 controls (40 benign tumors and thirty three non-cancerous tissues) were employed in tissue microarray construction. Immunohistochemistry (IHC) staining was applied to reveal p-AMPK expression. This study was carried out in the pathology lab of King Abdulaziz University Hospital over a duration of 15 months and was completed on 7th July 2018. Results: Phosphorylated AMPK was identified in 133 (85.8%) of colorectal cancers and 73 (100%) control cases. Histologic type was noticeably correlated with p-AMPK immunostaining (P= 0.001), high score of p-AMPK immunostaining is more frequent in control cases. Considerable varied survival models were observed with neoplasm size, metastatic tumor, recurrence and disease relapse (P-values <0.01). Survival estimates are considerably healthier in positive cases which have one of the following features size less than 5 cm, absence of metastatic tumor, no reoccurrence or disease relapse. Conclusions: The present study showed a reduction in the IHC staining of p-AMPK in colorectal cancer compared with controls. IHC staining of p-AMPK can be a supportive marker in predicting prognosis and survival estimates of colorectal tumors with specific clinical factors.
- Subjects
COLORECTAL cancer; BENIGN tumors; TUMOR growth; DISEASE relapse; LARGE intestine
- Publication
Pakistan Journal of Medical Sciences, 2019, Vol 35, Issue 3, p685
- ISSN
1682-024X
- Publication type
Article
- DOI
10.12669/pjms.35.3.159