We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Abnormalities in resting-state EEG microstates are a vulnerability marker of migraine.
- Authors
Li, Yansong; Chen, Guoliang; Lv, Jing; Hou, Lei; Dong, Zhao; Wang, Rongfei; Su, Min; Yu, Shengyuan
- Abstract
Background: Resting-state EEG microstates are thought to reflect brief activations of several interacting components of resting-state brain networks. Surprisingly, we still know little about the role of these microstates in migraine. In the present study, we attempted to address this issue by examining EEG microstates in patients with migraine without aura (MwoA) during the interictal period and comparing them with those of a group of healthy controls (HC). Methods: Resting-state EEG was recorded in 61 MwoA patients (50 females) and 66 HC (50 females). Microstate parameters were compared between the two groups. We computed four widely identified canonical microstate classes A-D. Results: Microstate classes B and D displayed higher time coverage and occurrence in the MwoA patient group than in the HC group, while microstate class C exhibited significantly lower time coverage and occurrence in the MwoA patient group. Meanwhile, the mean duration of microstate class C was significantly shorter in the MwoA patient group than in the HC group. Moreover, among the MwoA patient group, the duration of microstate class C correlated negatively with clinical measures of headache-related disability as assessed by the six-item Headache Impact Test (HIT-6). Finally, microstate syntax analysis showed significant differences in transition probabilities between the two groups, primarily involving microstate classes B, C, and D. Conclusions: By exploring EEG microstate characteristics at baseline we were able to explore the neurobiological mechanisms underlying altered cortical excitability and aberrant sensory, affective, and cognitive processing, thus deepening our understanding of migraine pathophysiology.
- Subjects
MIGRAINE diagnosis; BIOMARKERS; EVOKED potentials (Electrophysiology); ELECTROENCEPHALOGRAPHY; PSYCHOLOGICAL vulnerability; MIGRAINE; RELAXATION for health; COMPARATIVE studies; DESCRIPTIVE statistics; BRAIN waves
- Publication
Journal of Headache & Pain, 2022, Vol 23, Issue 1, p1
- ISSN
1129-2369
- Publication type
Article
- DOI
10.1186/s10194-022-01414-y