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- Title
Noncoding RNAs and Virus and Treatment in Allergic Rhinitis.
- Authors
Lei, Zhu; Feng, Guangrui; Wang, Zhiguo; Ning, Zhifeng
- Abstract
Allergic rhinitis (AR) is a type I hypersensitivity reaction disease caused by inhaled allergens and immunoglobulin E (IgE)-mediated. Noncoding RNA (ncRNA) is an important regulator involved in gene expression and can be detected in the cytoplasm or extracellular fluid, which mainly includes microRNAs (miRNA, length 22–24 nucleotides), long noncoding RNAs (lncRNA, length >200 nucleotides), and circRNAs. LncRNA and miRNA both participate in the regulation of immune function. Some respiratory viral infections can aggravate allergic rhinitis, such as a respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). However, the interaction between viral infection and allergy is complex and the mechanism is still unclear. In this review, we summarized the interactions of noncoding RNAs and viruses in the occurrence and development of AR, along with the treatments focusing on the noncoding RNAs in the past five years.
- Subjects
RHINITIS treatment; RNA physiology; VIRUSES; RHINITIS; GENE expression
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2022, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2022/1979447