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- Title
The Placental Syncytium and the Pathophysiology of Preeclampsia and Intrauterine Growth Restriction.
- Authors
Guller, Seth; Ma, Yula Y.; Fu, Han‐Hsuan; Krikun, Graciela; Abrahams, Vikki M.; Mor, Gil
- Abstract
Preeclampsia is associated with an increased release of factors from the placental syncytium into maternal blood, including the antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluable endoglin, the antifibrinolytic factor plasminogen activator inhibitor-1, prostanoids, lipoperoxides, cytokines, and microparticles. These factors are suggested to promote maternal endothelium dysfunction and are associated with placental damage in pregnancies also complicated with intrauterine growth restriction (IUGR). In this report, we briefly describe the interaction of syncytial factors with hypoxia, reactive oxygen species, and apoptosis in the pathophysiology of preeclampsia and IUGR. Given the critical role of the syncytium in these complications of pregnancy, we also present a novel methodology in which laser capture microdissection followed by Western blotting is used to assess levels of syncytial Fas ligand, a key protein in the apoptotic cascade.
- Subjects
FETAL development; PREECLAMPSIA diagnosis; PREGNANCY complications; FETAL pathophysiology; PATHOLOGICAL physiology; VASCULAR endothelial growth factors; ANTIFIBRINOLYTIC agents; TISSUE plasminogen activator; WESTERN immunoblotting; PREECLAMPSIA
- Publication
Annals of the New York Academy of Sciences, 2008, Vol 1127, p129
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1434.015