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- Title
MS07116 Sodium Selenosulfate Synthesis and Demonstration of Its In Vitro Cytotoxic Activity Against HepG2, Caco2, and Three Kinds of Leukemia Cells.
- Authors
Jinsong Zhang; Hongjuan Lu; Xufang Wang
- Abstract
Abstract The biological profile of sodium selenosulfate, Na2SeSO3, is still largely unknown. The present study found that sodium sulfite reacted with elemental selenium at nanoparticle size already at 37°C to yield sodium selenosulfate. Additionally, selenosulfate was obtained by mixing sodium selenite, glutathione, and sodium sulfite at room temperature. In vitro, sodium selenosulfate killed HepG2 or Caco2 cells, in a dose-dependent fashion, and 12.5 μM fully suppressed their proliferation. In addition, sodium selenosulfate showed a consistent cytotoxic effect when added to three kinds of leukemia cell lines (HL60, T lymph adenoma, and Daudi).
- Subjects
SODIUM selenite; ORGANIC synthesis; LEUKEMIA; CANCER cells; GLUTATHIONE; CELL lines; SELENIUM
- Publication
Biological Trace Element Research, 2008, Vol 125, Issue 1, p13
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-007-8044-0