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- Title
Palladium(0)-Catalyzed Single and Double Isonitrile Insertion: A Facile Synthesis of Benzofurans, Indoles, and Isatins.
- Authors
Senadi, Gopal Chandru; Hu, Wan‐Ping; Boominathan, Siva Senthil Kumar; Wang, Jeh‐Jeng
- Abstract
A palladium(0)-catalyzed cascade process consisting of isonitrile insertion and α-Csp3H cross-coupling can be achieved for the synthesis of benzofurans and indoles. The construction of isatins by a Pd-catalyzed cascade reaction incorporating double isonitrile insertion, amination, and hydrolysis has also been achieved. The key features of this work include diverse heterocycle synthesis, phosphine-ligand-free reaction conditions, a one-pot procedure, simple and commercially available starting materials, broad functional-group compatibility, and moderate to good reaction yields.
- Subjects
PALLADIUM; BENZOFURANS; ISATIN; ISOCYANIDES; AMINATION
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 3, p998
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201405933