We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-Lived Spin States for Low-Field Hyperpolarized Gas MRI.
- Authors
Kovtunov, Kirill V.; Truong, Milton L.; Barskiy, Danila A.; Koptyug, Igor V.; Coffey, Aaron M.; Waddell, Kevin W.; Chekmenev, Eduard Y.
- Abstract
Parahydrogen induced polarization was employed to prepare a relatively long-lived correlated nuclear spin state between methylene and methyl protons in propane gas. Conventionally, such states are converted into a strong NMR signal enhancement by transferring the reaction product to a high magnetic field in an adiabatic longitudinal transport after dissociation engenders net alignment (ALTADENA) experiment. However, the relaxation time T1 of ∼0.6 s of the resulting hyperpolarized propane is too short for potential biomedical applications. The presented alternative approach employs low-field MRI to preserve the initial correlated state with a much longer decay time TLLSS=(4.7±0.5) s. While the direct detection at low-magnetic fields (e.g. 0.0475 T) is challenging, we demonstrate here that spin-lock induced crossing (SLIC) at this low magnetic field transforms the long-lived correlated state into an observable nuclear magnetization suitable for MRI with sub-millimeter and sub-second spatial and temporal resolution, respectively. Propane is a non-toxic gas, and therefore, these results potentially enable low-cost high-resolution high-speed MRI of gases for functional imaging of lungs and other applications.
- Subjects
PROPANE; HYPERPOLARIZATION (Cytology); GASES; PARAHYDROGEN; MAGNETIC resonance imaging; POLARIZATION (Nuclear physics)
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 45, p14629
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201405063