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- Title
Strong Aphicidal Activity of GlcNAc(β1→4)Glc Disaccharides: Synthesis, Physiological Effects, and Chitinase Inhibition.
- Authors
Dussouy, Christophe; Bultel, Laurent; Saguez, Julien; Cherqui, Anas; Khelifa, Mounia; Grand, Eric; Giordanengo, Philippe; Kovensky, José
- Abstract
The synthesis of four GlcNAc(β1→4)Glc disaccharides containing 2- O-acetyl and/or 6-sulfate groups was performed in high yields with total 1,2- trans stereoselectivity. These disaccharides were evaluated as candidates for insect chitinase inhibition and aphicidal activity. All the compounds prepared displayed physiological effects on M. persicae aphids; however, the inhibition of chitinases of different sources (bacteria, fungus, and aphid) followed different patterns according to subtle structural characteristics.
- Publication
Chemistry - A European Journal, 2012, Vol 18, Issue 32, p10021
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201200887