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- Title
Modelling white matter with spherical deconvolution: How and why?
- Authors
Dell'Acqua, Flavio; Tournier, J.‐Donald
- Abstract
Since the realization that diffusion MRI can probe the microstructural organization and orientation of biological tissue in vivo and non‐invasively, a multitude of diffusion imaging methods have been developed and applied to study the living human brain. Diffusion tensor imaging was the first model to be widely adopted in clinical and neuroscience research, but it was also clear from the beginning that it suffered from limitations when mapping complex configurations, such as crossing fibres. In this review, we highlight the main steps that have led the field of diffusion imaging to move from the tensor model to the adoption of diffusion and fibre orientation density functions as a more effective way to describe the complexity of white matter organization within each brain voxel. Among several techniques, spherical deconvolution has emerged today as one of the main approaches to model multiple fibre orientations and for tractography applications. Here we illustrate the main concepts and the reasoning behind this technique, as well as the latest developments in the field. The final part of this review provides practical guidelines and recommendations on how to set up processing and acquisition protocols suitable for spherical deconvolution. Diffusion MRI can probe non‐invasively and in vivo the microstructural organization and the orientation of white matter in the human brain. Diffusion tensor imaging was the first model to be widely adopted in clinical and research applications, but it has also shown important limitations. Alternative methods have been developed to extract and better describe multiple populations of fibre orientations in the brain. Here we review these techniques, focusing particularly on spherical deconvolution, its principles and how this method can be practically applied in real studies.
- Publication
NMR in Biomedicine, 2019, Vol 32, Issue 4, pN.PAG
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.3945