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- Title
Clinicopathologic features of lingual canine T-zone lymphoma.
- Authors
Harris, L. J.; Rout, E. D.; Hughes, K. L.; Labadie, J. D.; Boostrom, B.; Yoshimoto, J. A.; Cannon, C. M.; Avery, P. R.; Ehrhart, E.J.; Avery, A. C.
- Abstract
Canine T-zone lymphoma (TZL) is a subtype of T-cell lymphoma characterized by unique histologic pattern and cytomorphology, immunophenotypic loss of CD45 expression, and an indolent clinical behaviour. Dogs with TZL typically present with 1 or more enlarged lymph nodes and/or lymphocytosis. We describe a novel extranodal presentation of TZL involving the tongue. Twelve dogs with tongue masses were diagnosed with lingual TZL based on a variable combination of immunophenotyping via flow cytometry, cytology, histopathology, immunohistochemistry and/or PCR for antigen receptor rearrangement (PARR) assay. Eleven dogs exhibited concurrent lymphocytosis and/or lymph node enlargement. Three cases were initially diagnosed as plasma cell tumours based on histology alone, thereby revealing a potential diagnostic challenge. Seven dogs achieved clinical remission and 4 achieved stable disease following variable treatment, consistent with the indolent nature of typical TZL involving the lymph nodes and peripheral blood. In 1 case the TZL resulted in progressive disease and failure to respond to treatment. In this case, the TZL exhibited histologic features of a higher grade neoplasm. This case series highlights a unique presentation of TZL and identifies a new differential diagnosis for lingual neoplasia. In this study, we characterize the clinical presentation, diagnostic features and patient outcomes of 12 dogs with lingual TZL.
- Subjects
LYMPHOMAS in dogs; T-cell lymphoma; LYMPH nodes; LYMPHOCYTOSIS; TONGUE tumors; DIAGNOSIS
- Publication
Veterinary & Comparative Oncology, 2018, Vol 16, Issue 1, p131
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12322