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- Title
Hospital outcomes in pediatric patients with Prader-Willi syndrome (PWS) undergoing orthopedic surgery: A 12-year analysis of national trends in surgical management and inpatient hospital outcomes.
- Authors
McQuivey, Kade S.; Chung, Andrew S.; Jones, Michael R.; Makovicka, Justin L.; Christopher, Zachary K.; Brinkman, Joseph C.; Belthur, Mohan
- Abstract
<bold>Background: </bold>The incidence of orthopedic disorders amongst patients with Prader-Willi Syndrome (PWS) is high when compared to the general pediatric population. The purpose of this retrospective study was to define the most commonly performed orthopedic procedures in pediatric patients with PWS and to characterize the peri-operative outcomes of these patients.<bold>Methods: </bold>The Kids Inpatient Database (KID) was queried to collect data and identify all pediatric patients with PWS who underwent orthopedic procedures from 2001 to 2012. A total of 3684 patients with PWS were identified, 334 of who underwent an orthopedic procedure. Population demographics, comorbidities, and specific procedures undergone were defined. The incidences of postoperative complications and length of associated hospital stay were additionally evaluated.<bold>Results: </bold>Mean age of patients in this sample was 10.33 years (SD 4.5). The most common comorbidities included obesity (18.1%), chronic pulmonary disease (14.1%), hypothyroidism (5.1%), hypertension (5.1%), and uncomplicated diabetes (4%). Common procedures were spinal fusion (165/334, 49%) and lower extremity procedures (50/334, 15%). Complications included acute blood loss anemia, device related complications, pneumonia, sepsis, and urinary tract infections. The overall complication rate was 35.6%. Average hospital lengths of stay for patients undergoing spinal fusion was 6.68 days (SD 4.13), lower extremity orthopedic procedure was 5.65 days (SD 7.4), and all other orthopedic procedures was 7.74 days (SD 16.3).<bold>Conclusions: </bold>Orthopedic disorders are common in patients with PWS. Consequently, spinal fusions and lower extremity procedures are commonly performed in this patient population. Associated comorbid conditions may negatively impact surgical outcomes in these patients. This information should prove useful in the peri-operative management of patients with PWS undergoing orthopedic surgery and for shared decision making with families.
- Subjects
CHILD patients; PRADER-Willi syndrome; CHILDREN'S hospitals; ORTHOPEDIC surgery; URINARY tract infections; HOSPITAL administration; MUSCULOSKELETAL system diseases; HOSPITALS; SPINAL fusion; RETROSPECTIVE studies; IMPACT of Event Scale; QUESTIONNAIRES; DISEASE complications
- Publication
Journal of Orthopaedic Science, 2022, Vol 27, Issue 6, p1304
- ISSN
0949-2658
- Publication type
journal article
- DOI
10.1016/j.jos.2021.08.005