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- Title
Applications of Gelatin Methacryloyl (GelMA) Hydrogels in Microfluidic Technique-Assisted Tissue Engineering.
- Authors
Liu, Taotao; Weng, Wenxian; Zhang, Yuzhuo; Sun, Xiaoting; Yang, Huazhe; Madbouly, Samy
- Abstract
In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed.
- Subjects
TISSUE engineering; HYDROGELS; GELATIN; MICROFLUIDIC devices; BIOMATERIALS; RAW materials; ENGINEERING simulations; BIOCOMPATIBILITY
- Publication
Molecules, 2020, Vol 25, Issue 22, p5305
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25225305