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- Title
Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.
- Authors
Offenbacher, Adam R.; Holman, Theodore R.; Nebra, Noel
- Abstract
Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-limiting steps of catalysis. Herein, the kinetic and structural evidence that describes the allosteric regulation of plant and animal lipoxygenase chemistry by fatty acids and their derivatives are summarized.
- Subjects
ALLOSTERIC regulation; LIPOXYGENASES; PLANT enzymes; FATTY acids; FATTY acid oxidation
- Publication
Molecules, 2020, Vol 25, Issue 15, p3374
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25153374