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- Title
Predicting Drug Resistance Using Deep Mutational Scanning.
- Authors
Pines, Gur; Fankhauser, Reilly G.; Eckert, Carrie A.; McPhee, Derek J.
- Abstract
Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences. Recent genome editing technologies based on high-throughput DNA synthesis and sequencing may help to predict mutations resulting in resistance by testing large mutagenesis libraries. Here we describe the rationale of this approach, with examples and relevance to drug development and resistance in malaria.
- Subjects
DRUG resistance; DNA synthesis; DRUG abuse; GENOME editing; MUTAGENICITY testing; MUTAGENESIS
- Publication
Molecules, 2020, Vol 25, Issue 9, p2265
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25092265