We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites.
- Authors
Jianxin Chen; Xueling Ma; Kuo Gao; Yong Wang; Huihui Zhao; Hao Wu; Juan Wang; Hua Xie; Yulin OuYang; Liangtao Luo; Shuzhen Guo; Jing Han; Bing Liu; Wei Wang
- Abstract
The object of this study was to identify the major active ingredients of the Chinese Traditional Medicine Jiang-Zhi-Ning (JZN) based on the high performance liquid chromatography (HPLC) profiles of plasma samples obtained from beagle dogs at different times after intragastric administration of JZN, crude JZN extracts, different extracted fractions, different subfractions of the active fraction and different isolated ingredients. 2-Hydroxy-1-methoxyaporphin (2H1M), an alkaloid from Nelumbo nucifera, one of the herbs that make up JZN, was identified as the constituent showing the major pharmacodynamic effect. The major metabolites of 2H1M were analyzed and identified as N-demethyl-2-hydroxy-1-methoxyaporphine-2-O-glycuronic acid, 2-hydroxy-1-methoxyaporphine-2-O-glycuronic acid and 2-hydroxy-1-methoxy-aporphine-2-O-sulphate. This study provided a comprehensive insight into the active components of JZN.
- Subjects
CHINESE medicine; LIQUID chromatography; HERBAL medicine; ALKALOIDS; METABOLITES
- Publication
Molecules, 2012, Vol 17, Issue 8, p9855
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17089855