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- Title
Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity.
- Authors
Reddy, Kachi R. Kishore Kumar; Longato, Giovanna B.; de Carvalho, João E.; Ruiz, Ana L. T. G.; Silva Jr., Luiz F.
- Abstract
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI50 = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.
- Subjects
CELL proliferation; IODINE compounds synthesis; PRINS reaction; CANCER cells; CELL lines; PREVENTION
- Publication
Molecules, 2012, Vol 17, Issue 8, p9621
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17089621