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- Title
Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate.
- Authors
Shouxin Zhou; Chao Tian; Chao Li; Ying Guo; Xiaowei Wang; Junyi Liu; Zhili Zhang
- Abstract
An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8- tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this method, the byproducts of carbonnitrogen bond hydrogenolysis in traditional synthetic strategy can be completely avoided.
- Subjects
TETRAHYDROFOLATE dehydrogenase; AZIRIDINES; PTERIDINES; AROMATIC amines; TACRINE; HETEROCYCLIC compounds; CHEMICAL derivatives
- Publication
Molecules, 2012, Vol 17, Issue 5, p5604
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules17055604