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- Title
The sero-prevalence of anti-adenovirus 5 neutralizing antibodies is independent of a chronic hepatitis B carrier state in China.
- Authors
Huang, Dao; Hennequi, Marie; Elvachev, Alexei; Menguy, Thierry; Silvestre, Nathalie; Yu, DeMin; Han, Yue; Inchauspé, Geneviève; Zhang, Xinxin; Zhu, Ren
- Abstract
We investigated the prevalence of neutralizing antibodies (NA) to human Adenovirus (Ad) 5 both in healthy subjects (HS) and Chronic Hepatitis B (CHB) patients in Shanghai. Detection of anti-Ad5 NA (percentage of detection and titers) was similar between HS and CHB patients. A high percentage of subjects harbored no detectable antibodies (32.2 %) while proportion of subjects displaying very high antibody titers was low (4 %). Neither demographic factors (gender, age, health) nor AST/ALT or HBV circulating DNA titers affected detection of Ad5-specific NA. These observations pave the ground for development of Ad5-based immunotherapeutics aiming at treating CHB patients in China.
- Subjects
SHANGHAI (China); CHRONIC hepatitis B; ADENOVIRUSES; SEROPREVALENCE; ANTIVIRAL agents; IMMUNOTHERAPY; DIAGNOSIS; THERAPEUTICS
- Publication
Archives of Virology, 2015, Vol 160, Issue 4, p1125
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-015-2333-2