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- Title
Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10.
- Authors
Uchiyama, Jumpei; Rashel, Mohammad; Takemura, Iyo; Kato, Shin-ichiro; Ujihara, Takako; Muraoka, Asako; Matsuzaki, Shigenobu; Daibata, Masanori
- Abstract
Bacteriophage (phage) KPP10 has been used in experimental phage therapies directed against P. aeruginosa infections. To examine the eligibility of phage KPP10 as a therapeutic phage, its genome was analyzed. The genomic DNA was shown to be 88,322 bp long, with 158 open reading frames (ORFs), and three tRNA genes were predicted. No ORF-encoded pathogenicity or lysogenization factor was predicted. A comparative genomic analysis revealed that phage KPP10, together with phage PAK_P3, can be grouped as a new type of lytic phage infecting P. aeruginosa. Phage KPP10 is considered to be suitable for therapeutic purposes because it is a lytic phage without ORF-encoded pathogenicity or a lysogenization factors.
- Subjects
VIRAL genetics; PSEUDOMONAS aeruginosa infections; BACTERIOPHAGES; OPEN reading frames (Genetics); COMPARATIVE genomics; PATHOGENIC bacteria; VIRUSES
- Publication
Archives of Virology, 2012, Vol 157, Issue 4, p733
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-011-1210-x