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- Title
Taurine Reduces Liver Damage in Non-Alcoholic Fatty Liver Disease Model in Rats by Down-Regulating IL-9 and Tumor Growth Factor TGF-β.
- Authors
Yao, Z.; Liang, G.; Lv, Z. L.; Lan, L. C.; Zhu, F. L.; Tang, Q.; Huang, L.; Chen, X. Q.; Yang, M. X.; Shan, Q. W.
- Abstract
The study employed a rat model to examine the effects of taurine (Tau) on prevention and therapy of non-alcoholic fatty liver disease (NAFLD). In model rats maintained on a high-fat diet (HFD), the serum levels of ALT, AST, triglycerides, cholesterol, and LDL were higher than the corresponding levels in normal control and NP groups (p<0.05). In Tau-prevention and Tau-treatment groups, the serum levels of AST and triglycerides were lower than in HFD rats (p<0.05). In HFD rats, diffuse fatty degeneration and infiltration with inflammatory cells was observed in the liver; in the ileal mucosa, the villi were fractured or absent, the epithelium was exfoliated and infiltrated with inflammatory cells. The levels of TGF-β, IL-9, and their mRNA in the liver and ileal mucosa of HFD rats were significantly higher than in normal control and NP groups (p<0.05). In Tau-prevention and Tau-treatment groups, these levels were significantly lower than in HFD rats (p<0.05). Thus, TGF-β and IL-9 can be implicated in NAFLD genesis, while Tau can preventively or therapeutically diminish the damage to the liver and ileal mucosa in rats with this disease by down-regulating the expression of TGF-β and IL-9.
- Subjects
NON-alcoholic fatty liver disease; TRANSFORMING growth factors; ANIMAL disease models; RAT diseases; TAURINE; NEUROFIBRILLARY tangles
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 171, Issue 5, p638
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05285-2