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- Title
Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease.
- Authors
Neganova, M. E.; Klochkov, S. G.; Shevtsova, E. F.; Bogatyrenko, T. N.; Mishchenko, D. V.
- Abstract
Antioxidant activity of a pharmaceutical substance hypocard was compared with activity of nitromalic acid and well-known agents nicorandil and Mexidol. The ability of these substances to inhibit spontaneous and oxidant-induced LPO process in rat brain homogenate was analyzed. The mechanisms of these effects were studied. The antioxidant properties of hypocard manifested in the inhibition of Fe(II)-induced LPO were significantly more pronounced in comparison with Mexidol and nicorandil.
- Subjects
LABORATORY rats; ANTIOXIDANTS; CHEMICAL inhibitors; OXIDATIVE stress; NICORANDIL
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 166, Issue 1, p46
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4286-4