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- Title
Breast cancer characteristics are modified by first trimester human placenta: in vitro co-culture study.
- Authors
Tartakover-Matalon, S.; Mizrahi, A.; Epstein, G.; Shneifi, A.; Drucker, L.; Pomeranz, M.; Fishman, A.; Radnay, J.; Lishner, M.
- Abstract
BACKGROUND: Pregnant women with breast cancer present with a more advanced disease compared with non-pregnant women. Nevertheless, breast cancer metastasis to the placenta is rare. Trophoblast/tumor implantations share the same biochemical mediators, while only the first is stringently controlled. We hypothesized that the same mechanisms that affect/restrain placental implantation may inhibit metastatic growth in the placenta. We aimed to analyze the effects of human placenta on breast cancer cells.
- Subjects
BREAST cancer; PREGNANCY complications; METASTASIS; PLACENTA tumors; TROPHOBLASTIC tumors; DIAGNOSIS; TUMOR treatment
- Publication
Human Reproduction, 2010, Vol 25, Issue 10, p2441
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deq227