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- Title
Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.
- Authors
Price, Stephen R.; Evans, Philip R.; Nagai, Kiyoshi
- Abstract
Presents research which determined the crystal structure of a ternary complex between the spliceosomal U2B"/U2A' protein complex and hairpin-loop IV of U2 small nuclear RNA. U2B" binding; Activity of the concave surface of a parallel beta-sheet of U2A'; Activity of the basic carboxy-terminal region of U2A'; Protein-protein interaction regulating RNA-binding specificity; Discrimination between cognate RNA hairpins.
- Subjects
PROTEINS; RNA; PROTEIN binding; CHEMICAL structure; STRUCTURE-activity relationships
- Publication
Nature, 1998, Vol 394, Issue 6694, p645
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/29234