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- Title
Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques.
- Authors
Sauermann, U.; Siddiqui, R.; Suh, Y.-S.; Platzer, M.; Leuchte, N.; Meyer, H.; Mätz-Rensing, K.; Stoiber, H.; Nürnberg, P.; Hunsmann, G.; Stahl-Hennig, C.; Krawczak, M.
- Abstract
In both human immunodeficiency virus-infected humans and simian immunodeficiency virus (SIV)-infected macaques, genes encoded in the major histocompatibility complex (MHC) class I region are important determinants of disease progression. However, compared to the human human lymphocyte antigen complex, the macaque MHC region encodes many more class I genes. Macaques with the same immunodominant class I genes express additional Mhc genes with the potential to influence the disease course. We therefore assessed the association between of the Mhc class I haplotypes, rather than single gene variants, and survival time in SIV-infected rhesus macaques (Macaca mulatta). DNA sequence analysis and Mhc genotyping of 245 pedigreed monkeys identified 17 Mhc class I haplotypes that constitute 10 major genotypes. Among 81 vaccination-naive, SIV-infected macaques, 71 monkeys carried at least one Mhc class I haplotype encoding only MHC antigens that were incapable of inducing an effective anti-SIV cytotoxic T lymphocytes response. Study of these macaques enabled us to relate individual Mhc class I haplotypes to slow, medium and rapid disease progression. In a post hoc analysis, classification according to disease progression was found to explain at least 48% of the observed variation of survival time.Genes and Immunity (2008) 9, 69–80; doi:10.1038/sj.gene.6364448; published online 20 December 2007
- Subjects
IMMUNOGENETICS; DISEASES; MAJOR histocompatibility complex; RHESUS monkeys; MACAQUES; AIDS; LYMPHOCYTES; DNA; LABORATORY monkeys; EDUCATION
- Publication
Genes & Immunity, 2008, Vol 9, Issue 1, p69
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364448