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- Title
Association of the multi-biomarker disease activity score with joint destruction in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha inhibitor treatment in clinical practice.
- Authors
Shintaro Hirata; Wanying Li; Satoshi Kubo; Shunsuke Fukuyo; Yasushi Mizuno; Kentaro Hanami; Norifumi Sawamukai; Kunihiro Yamaoka; Kazuyoshi Saito; Defranoux, Nadine A.; Yoshiya Tanaka
- Abstract
Objective: Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-a inhibitors. Methods: Change (D) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores were examined retrospectively by Spearman's rank correlation coefficient in patients (N=83) with RA initiating TNF-inhibitor treatment. Relative risk (RR) of ΔmTSS40.5 for low MBDA score and 28-joint count disease activity score (DAS28) categories and associations between ΔmTSS and MBDA score categories conditional on DAS28 categories were assessed. Results: At 52 weeks, 34% of patients had ΔmTSS40.5 and 12% had ΔmTSS43. Strongest correlations were observed between DmTSS and MBDA score (r=0.47) or DAS28 (r=0.42) at Week 24 and for area under the curve at Week 52 (MBDA score: r=0.44, DAS28: r=0.41), all p50.001. At Week 24, RR of DmTSS40.5 for moderate/high MBDA score (30) or DAS28 (43.2) were 6.6 (p50.001) and 2.7 (p=0.005), respectively. Low DAS28 had greater risk of DmTSS40.5 at 52 weeks when MBDA score was 30 (p50.05). Conclusion: Higher MBDA score or DAS28 at Week 24 was associated with greater radiographic progression over 52 weeks of TNF-inhibitor treatment. MBDA score improved risk discrimination for radiographic progression within DAS28 categories.
- Subjects
RHEUMATOID arthritis treatment; BIOMARKERS; TUMOR necrosis factors; DISEASE progression; MEDICAL statistics
- Publication
Modern Rheumatology, 2016, Vol 26, Issue 6, p850
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/14397595.2016.1153449