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- Title
PORPHYROMONAS GINGIVALIS MAY INDUCED POLYCYSTIC OVARY SYNDROME : A REVIEW.
- Authors
Handayani, Roni; Rizki Azis, Zulfikran Mohammad; Nurani, Ayuningtyas W.; Rahmawati, Septyana E.; Asih, Estu Sami; Shoukat, Shahzad; Budhy, Theresia Indah; Destiawan, Rian A.; Hassan, Hamid
- Abstract
PCOS (Polycystic ovary syndrome) is a hormonal disease that affects women, affecting metabolism and causes hirsutism, hyperandrogenism, ovulatory dysfunction, monthly irregularities, and infertility. There is currently no apparent certainty about the relationship between PCOS and the oral microbiome. The purpose of this article is to study the possible associationsthat exist about the oral microbiome’s connection to PCOS. Various causes, including genetic and environmental influences, can cause this condition. Genes that have a role in regulating androgen hormones are known as genetic factors that impact. Insulin resistance can be caused by environmental factors such as obesity and the growth of the microbiota. Insulin resistance is a common symptom of a number of illnesses, including PCOS. Dysbiosis that occurs in microbiomes such as Porphyromonas gingivalis can cause balance disorders that lead to hormonal disorders. The dysbiosis that occurs by this microbiota may increase BCAA levels, insulin sensitivity, and porous alveolar bone are likely to be followed by increased biofilm growth and colonization of Porphyromonas gingivalis. Porphyromonas gingivalis can cause insulin resistance ( IR ) through Branched-chain amino acids ( BCAAs ) pathways. Opportunities in the relationship between the oral microbiota and PCOS currently need to be investigated.
- Subjects
PORPHYROMONAS gingivalis; POLYCYSTIC ovary syndrome; HYPERTRICHOSIS; HYPERANDROGENISM; INSULIN resistance
- Publication
Biochemical & Cellular Archives, 2021, Vol 21, Issue 2, p3229
- ISSN
0972-5075
- Publication type
Article