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- Title
Agudización severa de EPOC: Abriendo la puerta para el desarrollo de herramientas y dispositivos simples.
- Authors
Sánchez-Bustillos, Marco Hugo
- Abstract
Background: Left heart failure (LHF) is commonly associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) but its role is often underestimated. Aim of the study: To evaluate the performance of a new diagnostic technique based on the measurement of the pulse amplitude ratio (PAR) using non-invasive ventilation (NIV) for the early identification LHF in patients admitted to the emergency department (ED) for AECOPD. Results: 73 patients were included in this study: 32 in LHF group and 41 in non LHF- group. The two groups had comparable demographic and clinical characteristics at admission. The mean values of PARNIV was significantly higher among LHF patients (0.86 vs. 0.71; p < 0.01). The area under the receiver operating characteristic curve of PARNIV was 0.75. Using the best cut-off (0.6), the sensitivity of PARNIV was 93% with a specificity 21%, a positive predictive value of 48%, and a negative predictive value of 81%. Correlation between PARNIV and BNP was significant (r = 0.52; p = 0.002). Conclusion: Measurement of PARNIV in patients presenting to the ED with AECOPD had a good diagnostic performance for the detection of LHF and could represent an interesting alternative for the currently available methods. Trial registration: The study was registered in the Clinical Trial Registration System (clinicaltrials.gov) under the study number NCT05189119, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000BOO4&selectacti on=Edit&uid=U0000QAM&ts=2&cx=qrmluh.
- Publication
Kompass Neumología, 2023, Vol 5, Issue 2, p64
- ISSN
2624-9065
- Publication type
Article
- DOI
10.1159/000530792