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- Title
Sustained antigen delivery improves germinal center reaction and increases antibody responses in neonatal mice.
- Authors
Lotspeich-Cole, Leda; Parvathaneni, Swetha; Sakai, Jiro; Liu, Lunhua; Takeda, Kazuyo; Lee, Robert C.; Akkoyunlu, Mustafa
- Abstract
Neonates and young infants are known to have limited responses to pediatric vaccines due to reduced germinal center formation. Extended vaccine antigen dosing was previously shown to expand germinal center formation and improve humoral responses in adult mice. We report that sustained antigen delivery through sequential dosing overcomes neonatal limitations to form germinal center reactions and improves humoral immunity. Thus, vaccine strategies that extend the release of vaccine antigens may reduce the number of doses, and time needed, to achieve protective immunity in neonates and young infants.
- Subjects
GERMINAL centers; ANTIBODY formation; IMMUNOGLOBULINS; ANTIGENS; HUMORAL immunity; B cells; MICE
- Publication
NPJ Vaccines, 2024, Vol 9, Issue 1, p1
- ISSN
2059-0105
- Publication type
Article
- DOI
10.1038/s41541-024-00875-3