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- Title
Zinc is a novel intracellular second messenger.
- Authors
Yamasaki, Satoru; Sakata-Sogawa, Kumiko; Hasegawa, Aiko; Suzuki, Tomoyuki; Kabu, Koki; Sato, Emi; Kurosaki, Tomohiro; Yamashita, Susumu; Tokunaga, Makio; Nishida, Keigo; Hirano, Toshio
- Abstract
Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events. In this study, we report that the cross-linking of the high affinity immunoglobin E receptor (Fcε receptor I [Fcε RI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave. The zinc wave was dependent on calcium influx and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase activation. The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcεRI-mediated signaling. Collectively, our findings indicate that zinc is a novel intracellular second messenger.
- Subjects
ZINC; ENZYMES; TRANSCRIPTION factors; HOMEOSTASIS; NEUROTRANSMITTERS; SECOND messengers (Biochemistry); CELLULAR signal transduction; IMMUNOGLOBULIN E
- Publication
Journal of Cell Biology, 2007, Vol 177, Issue 4, p637
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.200702081