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- Title
A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations.
- Authors
Morag, Monika; Nawrot, Joanna; Siatkowski, Idzi; Adamski, Zygmunt; Fedorowicz, Tomasz; Dawid‐Pac, Renata; Urbanska, Maria; Nowak, Gerard
- Abstract
Background Arbutin is one of the most effective lightening substances. Serratula quinquefolia is a new source of its β-anomer. The HPLC method showed that the solid content of this compound in the dried plant raw material accounts for 6.86%. The leaves of Serratula quinquefolia do not contain hydroquinone. Aims To assess the efficacy of the aqueous extract from' leaf of five-leaf serratula as a skin-lightening agent. Patients/Methods We did a randomized, placebo-controlled, double-blind trial. The study involved 102 women aged 26-55, with two kinds of hyperpigmentary diseases: melasma and lentigo solaris. Patients were randomly assigned to one of the treatment groups: a study group ( N = 54) or a control group ( N = 48). The study group applied the cream with the aqueous extract from leaf of five-leaf serratula containing 2.51% of arbutin. The cream was applied twice a day on the discolored side for 8 weeks. Results The experimental data showed that the cream with the extract causes decreased level of melanin in the skin pigmentation spot. Clinical effect in the form of lightening and evening skin tone on the discolored side was observed in 75.86% of the female patients with melasma and 56.00 % of the female patients with lentigo solaris. Conclusions The cream with the aqueous extract from leaf of five-leaf serratula proved to be an effective and safe preparation for lightening skin discolorations (66.67 % of the female patients in the study group).
- Subjects
ARBUTIN; HUMAN skin color; PLACEBOS; GLUCOSIDES; CUTICLE
- Publication
Journal of Cosmetic Dermatology, 2015, Vol 14, Issue 3, p185
- ISSN
1473-2130
- Publication type
Article
- DOI
10.1111/jocd.12147