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- Title
First Report of an Escherichia coli Strain Carrying the Colistin Resistance Determinant mcr-1 from a Dog in South Korea.
- Authors
Moon, Dong Chan; Mechesso, Abraham Fikru; Kang, Hee Young; Kim, Su-Jeong; Choi, Ji-Hyun; Kim, Mi Hyun; Song, Hyun-Ju; Yoon, Soon-Seek; Lim, Suk-Kyung
- Abstract
We studied the presence of the mobile colistin resistance gene mcr-1 in Escherichia coli isolates recovered from fecal and urine samples of companion animals, that were collected from South Korea in 2018 and 2019. The mcr-1 gene was detected in one colistin-resistant E. coli isolated from a diarrheic dog. The isolate exhibited additional resistance to multiple antimicrobials, including fluoroquinolones and third-generation cephalosporins. The mcr-1 carrying isolate belonged to ST160. The pulsed-field gel electrophoresis pattern of our strain differed from those ST160 E. coli strains previously identified from chickens in Korea. The mcr-1 gene was identified in the IncI2 plasmid. It was also transferred to E. coli J53 recipient strain, with a conjugation efficiency of 2.8 × 10−4. Average nucleotide identity analysis demonstrated that the mcr-1-carrying plasmid in this study was closely related to those from patients in Korea. To the best of our knowledge, this is the first report of mcr-1 carrying E. coli from a companion animal in South Korea. Our findings support One Health approach is necessary to prevent the dissemination of this high-risk gene.
- Subjects
SOUTH Korea; COLISTIN; ESCHERICHIA coli; PULSED-field gel electrophoresis; DOGS; PETS
- Publication
Antibiotics (2079-6382), 2020, Vol 9, Issue 11, p768
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics9110768