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- Title
Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population.
- Authors
Quach, Huy Quang; Ovsyannikova, Inna G.; Grill, Diane E.; Warner, Nathaniel D.; Poland, Gregory A.; Kennedy, Richard B.
- Abstract
As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20–44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.
- Subjects
MEASLES; IMMUNOGLOBULIN G; SEROPREVALENCE; IMMUNOGLOBULINS; VACCINATION coverage
- Publication
Vaccines, 2022, Vol 10, Issue 11, p1859
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines10111859