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- Title
The liver as a target organ of retinoids
- Authors
Shiota, Goshi; Tsuchiya, Hiroyuki; Hoshikawa, Yoshiko
- Abstract
Abstract: Retinoids have several biological functions including cell growth, differentiation and apoptosis. In liver, retinoids are known to be associated with regeneration, fibrosis and carcinogenesis. The facts that retinoid droplets in stellate cells are lost with progression of liver disease and that effectiveness of an acyclic retinoid on second primary liver cancer suggest the importance of liver as a target organ of retinoids. Our recent work has indicated that retinoids have antioxidant effects in association with regulation of fatty acid metabolism. In this review article, we discussed the important function of retinoids in liver, mainly from molecular aspects.
- Subjects
RETINOIDS; CELL growth; CELL death; APOPTOSIS; FIBROSIS
- Publication
Hepatology Research, 2006, Vol 36, Issue 4, p248
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1016/j.hepres.2006.08.010