We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Longitudinal Characterization of the Mumps-Specific HLA-A2 Restricted T-Cell Response after Mumps Virus Infection.
- Authors
Lanfermeijer, Josien; Nühn, Marieke M.; Emmelot, Maarten E.; Poelen, Martien C. M.; van Els, Cécile A. C. M.; Borghans, José A. M.; van Baarle, Debbie; Kaaijk, Patricia; de Wit, Jelle
- Abstract
Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8+ T cells may play an important role in the response against MuV; however, little is known about the characteristics and dynamics of the MuV-specific CD8+ T-cell response after MuV infection. Here, we had the opportunity to follow the CD8+ T-cell response to three recently identified HLA-A2*02:01-restricted MuV-specific epitopes from 1.5 to 36 months post-MuV infection in five previously vaccinated and three unvaccinated individuals. The infection-induced CD8+ T-cell response was dominated by T cells specific for the ALDQTDIRV and LLDSSTTRV epitopes, while the response to the GLMEGQIVSV epitope was subdominant. MuV-specific CD8+ T-cell frequencies in the blood declined between 1.5 and 9 months after infection. This decline was not explained by changes in the expression of inhibitory receptors or homing markers. Despite the ongoing changes in the frequencies and phenotype of MuV-specific CD8+ T cells, TCRβ analyses revealed a stable MuV-specific T-cell repertoire over time. These insights in the maintenance of the cellular response against mumps may provide hallmarks for optimizing vaccination strategies towards a long-term cellular memory response.
- Subjects
VIRUS diseases; MUMPS; T cells; HUMORAL immunity; LONG-term memory
- Publication
Vaccines, 2021, Vol 9, Issue 12, p1431
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines9121431