We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of antiglaucoma drugs on the ocular surface in rabbits: a fixed-combination drug versus two concomitant drugs.
- Authors
Cho, Hyun; Park, Myoung; Moon, Jung
- Abstract
Purpose: We investigated the effects of a fixed-combination antiglaucoma drug and compared it with two concomitant antiglaucoma drugs on the ocular surface. Methods: Twenty-four rabbits were randomized into four groups. Group 1 was administered timolol, group 2 travoprost, group 3 a travoprost/timolol fixed-combination solution, and group 4 timolol and travoprost. Conjunctival impression cytology specimens were collected at baseline and weeks 1, 3, and 6, and conjunctival biopsy specimens at week 6. Results: The impression cytology study results were as follows: No statistically significant differences among group 1-3 at any time ( p > 0.05); a statistically significant difference between groups 3 and 4 at week 6 ( p = 0.003); a statistically significant difference between baseline and group 4 at week 6 ( p = 0.008). Conjunctival biopsy specimens of group 1-3 showed no distortion of the conjunctival epithelial structures, but group 4 showed decreased layers of epithelial cells with fewer periodic acid-Schiff (PAS) (+) goblet cells. Conclusions: A fixed-combination antiglaucoma drug is beneficial in reducing adverse ocular surface changes in long-term use. This is believed to be due to the smaller concentration of preservatives contained in the fixed-combination drug.
- Subjects
GLAUCOMA treatment; PHARMACODYNAMICS; BIOPSY; EXFOLIATIVE cytology; RABBITS
- Publication
Japanese Journal of Ophthalmology, 2011, Vol 55, Issue 6, p670
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-011-0078-3