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- Title
Using synthesized onion lachrymatory factor to measure age-related decreases in reflex-tear secretion and ocular-surface sensation.
- Authors
Higashihara, Hisayo; Yokoi, Norihiko; Aoyagi, Morihiro; Tsuge, Nobuaki; Imai, Shinsuke; Kinoshita, Shigeru
- Abstract
To use synthesized onion lachrymatory factor (SOLF) to investigate age-related changes in reflex-tear secretion and ocular-surface sensation. We separated 91 healthy volunteers into four groups: groups A, age 20–29 years; B, 30–39; C, 40–49; and D, older than 50 years. We exposed one eye of each subject to SOLF and measured the elapsed time until the subject’s limit of irritation tolerance (TLI) was reached and an increase in the tear meniscus radius (ΔR). After the SOLF stimulus, corneal sensitivity was examined by Cochet-Bonnet esthesiometry (CB), and reflex-tear secretion was examined by the Schirmer I-test (ST). TLI was significantly shorter in group A than in the other groups ( P < 0.0001), and the groups B and D also differed significantly from each other ( P = 0.0013). The increase in ΔR was significantly greater in group A than in group C ( P = 0.0306) or D ( P < 0.0001), and groups B ( P = 0.0002) and C ( P = 0.0308) also differed significantly from group D. There were no significant intergroup differences in the CB and ST results. An age-related decrease in reflex-tear secretion and ocular-surface sensation was revealed by the SOLF test but could not be detected by either CB or the ST.
- Subjects
ONIONS; LACRIMAL apparatus diseases; TEARS (Body fluid); EYE; BODY fluids; THERAPEUTICS
- Publication
Japanese Journal of Ophthalmology, 2010, Vol 54, Issue 3, p215
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-009-0786-0