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- Title
Persistent Epithelial Defects Due to Neurotrophic Keratopathy Treated with a Substance P-Derived Peptide and Insulin-Like Growth Factor 1.
- Authors
Teruo Nishida; Tai-ichiro Chikama; Naoyuki Morishige; Ryoji Yanai; Naoyuki Yamada; Jun Saito
- Abstract
Abstract Purpose The loss of corneal sensation results in the development of persistent corneal epithelial defects. The combination of a substance P-derived peptide, phenylalanine -glycine-leucine-methionine (FGLM)-amide, and insulin-like growth factor 1 (IGF-1) stimulates corneal epithelial migration in vitro and corneal epithelial wound closure in vivo. The clinical efficacy of eye drops containing FGLM-amide and IGF-1 for the treatment of persistent epithelial defects in individuals with neurotrophic keratopathy was examined in a prospective open study. Methods Eleven patients with persistent corneal epithelial defects associated with neurotrophic keratopathy were treated for up to 28 days by the administration of eye drops containing FGLM-amide and IGF-1. The course of epithelial healing was monitored by slit-lamp examination, and visual acuity was measured before and after treatment. Results Complete epithelial resurfacing was achieved in eight of the nine (89%) cases of persistent epithelial defects in the nine patients who received the full course of treatment. Epithelial defects had completely resurfaced in two of nine (22%) and five of nine (56%) cases within 1 and 2 weeks, respectively, after treatment initiation. No adverse effects of treatment were observed in any of the 11 patients. Conclusions Eye drops containing FGLM-amide and IGF-1 induced the rapid resurfacing of persistent epithelial defects in individuals with neurotrophic keratopathy. Jpn J Ophthalmol 2007;51:442–447 © Japanese Ophthalmological Society 2007
- Subjects
CORNEA diseases; VISUAL acuity; SOMATOMEDIN; EYE diseases; SUBSTANCE P; INFLAMMATORY mediators
- Publication
Japanese Journal of Ophthalmology, 2007, Vol 51, Issue 6, p442
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-007-0480-z